Example 304 Example 718 Example 562 10, p. 423 (2004); Vol. Obviously several unit dosage forms may be administered at about the same time. 0.027 By the application or adaptation of the methods described by Amin et al, J. Indian Chem, Soc., 1964, 41, 833, to 2-acetoxy-5-methylbenzoic acid, there was prepared 3-acetyl-5-methylsalicylic acid, m.p. Compound I-14 F-16 0.025 Compound B-61 This step can be performed by reacting the sulfonylbenzylamine derivative I-g with a corresponding carboxylic acid in the presence of a condensing agent and base. EXAMPLES Example 163 4-[3-(5-Chloro-2-ethanesulfonyl-benzylcarbamoyl)-5-trifluoromethoxy-benzyl]-piperazine-1-carboxylic acid tert-butyl ester The reaction solution was diluted with ethyl acetate, and the organic layer was washed with a saturated aqueous sodium bicarbonate solution, water, and saturated saline, and then dried over anhydrous sodium sulfate. Example 664 Trichloromonofluoromethane (2.7 g), dichlorodifluoromethane (9.4 g) and dichlorotetrafluoroethane (4.4 g) were then added, to give a total volume of 12.5 ml. INDUSTRIAL APPLICABILITY Compound P-8 The title compound was synthesized from (2-ethylsulfanyl-5-fluoro-phenyl)-hydrazine (Compound a5) and 3-trifluoromethyl-benzoic acid under the same conditions as for Compound A-1. The reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by silica gel column chromatography (ethyl acetate/n-hexane) to yield the title compound (152 mg, 81%) as a colorless solid. 10% palladium on carbon (15.0 mg) was added to a solution of benzyl (3S)-3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylcarbamoyl]piperidine-1-carboxylate (81.0 mg, 0.200 mmol) in MeOH (2.2 ml) under an argon atmosphere, and the mixture was stirred at room temperature for 16 hours under a hydrogen atmosphere. LCMS: m/z 500 [M+H]⁺ Soc. The title compound was synthesized from 3-chloropyridine-4-carbonitrile under the same conditions as for Compound a6. [2-Ethylsulfanyl-5-(trifluoromethyl)phenyl]hydrazine 475 LCMS: m/z 518 [M+H]⁺ N-(5-Chloro-2-ethanesulfonyl-benzyl)-4-((R)-2-dimethylaminomethyl-pyrrolidin-1-ylmethyl)-3-trifluoromethyl-benzamide 313 The mixture was brought cautiously to the reflux temperature and treated with acetyl chloride (3.45 g) dropwise during 15 minutes. mm Ethyl 3-chloro-5-methoxy-4-[[(3S)-3-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]piperidin-1-yl]methyl]benzoate Compound O-6 HPLC retention time: 0.40 min (analysis condition F) D-5 Compound p5 The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane) to yield the title compound (180 mg, yield: 98%) as a yellow oily substance. LCMS: m/z 598 [M+H]⁺ HPLC retention time: 0.49 min (analysis condition A) N-(5-Chloro-2-ethanesulfonyl-benzyl)-4-piperazin-1-ylmethyl-3-trifluoromethyl-benzamide Then, tert-butyl N-ethyl-N-[(3S)-piperidin-3-yl]carbamate (6.0 mg, 0.0263 mmol) was further added, and it was stirred at the same temperature for one hour. Example 178 HPLC retention time: 0.53 min (analysis condition A) HPLC retention time: 0.98 min (analysis condition A) HPLC retention time: 0.54 min (analysis condition A) However, bromoacetamide was used in place of 3-bromopropyne. Their isotopes include ²H, ³H, ¹³C, ¹⁴C, ¹⁵N, ¹⁷O, ¹⁸O, ³¹P, ³²P, ³⁵S, ¹⁸F, and ³⁶Cl. Example 132 5-Bromo-2-ethylsulfanyl-benzaldehyde O-methyl-oxime 513 4-[(S)-3-(Acetylamino-methyl)-pyrrolidin-1-ylmethyl]-N-(5-chloro-2-ethanesulfonyl-benzyl)-3-trifluoromethyl-benzamide LCMS: m/z 268 [M+H]⁺ Example 629 Sodium nitrite (80.7 mg, 1.17 mmol) was added, and the mixture was stirred for 20 minutes under ice-cooling, after which potassium iodide (1.22 g, 7.38 mmol) dissolved in water (1.5 ml) was added, followed by 30 minutes of stirring. Example 422 0.022 After the drying agent was removed by filtration, a crude product of (3-[(3R)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-3-yl]propanoic acid (66.1 mg) was obtained as a colorless solid by concentration under reduced pressure. The drying agent was removed by filtration, followed by concentration under reduced pressure. Example 33 LCMS: m/z 407 [M+H]⁺ 285 Compound f2 B-37 Ra and Rb are identical or different, each representing a hydrogen atom, C₁₋₆ alkyl group, C₂₋₆ alkynyl group, C₃₋₈ cycloalkyl group, 3- to 12-membered heterocycle, or —SO₂CH₃, wherein the C₁₋₆ alkyl group, C₃₋₈ cycloalkyl group, 3- to 12-membered heterocycle, or C₂₋₆ alkynyl group may be substituted with 1 to 5 halogen atoms, hydroxyl groups, C₁₋₆ alkoxy groups, amino groups, —CONH₂, mono-C₁₋₆ alkylamino groups, di-C₁₋₆ alkylamino groups, cyano groups, OCH₂Ph, and/or 3- to 12-membered heterocycles; as a colorless oily substance. The reaction mixture was warmed to 20° C.; and the precipitate was collected by filtration, washed with a mixed solution of ethanol/water (1:1, 2.16 L), and then dried under reduced pressure to yield the title compound (205 g, 66%) as a pale brown solid. The title compound was synthesized from 3-chloro-N-(5-chloro-2-ethanesulfonyl-benzyl)-4-piperazin-1-yl-5-trifluoromethoxy-benzamide (Compound J-2) under the same conditions as for Compound B-2. 0.024 I-4 Example 455 The combined organic layers were dried over anhydrous sodium sulfate. The mixture was stirred at 25° C. for 20 hours, and then most of the hydrogen bromide was removed by passing a stream of air through the mixture for 6 hours. {(S)-1-[4-(5-Chloro-2-ethanesulfonyl-benzylcarbamoyl)-2-trifluoromethyl-benzyl]-piperidin-3-ylmethyl}-carbamic acid tert-butyl ester Compound b15 333 Example 271 wherein A¹ represents N or CR¹; Compound o8 H-10 HPLC retention time: 0.68 min (analysis condition F) Preferred alkyl groups include alkyl groups with one to six carbon atoms (C₁₋₆; hereinafter, “Cp-q” means that the number of carbon atoms is p to q), C₁₋₅ alkyl groups, C₁₋₄ alkyl groups, and C₁₋₃ alkyl groups. Example 627 HPLC retention time: 0.40 min (analysis condition F) After washing with saturated saline, the organic layer was dried over anhydrous magnesium sulfate. Example 576 The resulting solid was filtered off, washed with petroleum ether (b.p. 0.032 The compounds of FIGS. D-25 Example 497 Example 155 Step IV-13 (4-Chloro-2-formyl-6-methoxyphenyl)trifluoromethanesulfonate 0.29 However, 3-chloro-5-(trifluoromethyl)benzoic acid was used in place of 3-bromo-5-(trifluoromethyl)benzoic acid. HPLC retention time: 1.08 min (analysis condition D) After one hour of stirring at 65° C., the reaction mixture was extracted with EtOAc. However, the reaction was performed using (S)-1-piperidin-3-ylmethyl-carbamic acid tert-butyl ester in place of (S)-1-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester. HPLC retention time: 0.81 min (analysis condition A) The reaction mixture was cooled to room temperature and then water was added, followed by extraction with ethyl acetate. The title compound was synthesized from 4-((R)-3-aminomethyl-piperidin-1-ylmethyl)-N-(5-chloro-2-ethanesulfonyl-benzyl)-3-trifluoromethyl-benzamide (Compound B-63) under the same conditions as for Compound B-2. 250°-251° C. (with decomposition) (recrystallized from ethanol); 2-hydroxy-3-methoxy-N-(tetrazol-5-yl)benzamide, m.p. 3-Bromopropyne (16.0 μl, 0.181 mmol) was added to a solution of 4-[[(3S)-3-aminopiperidin-1-yl]methyl]-3-chloro-N-[(5-chloro-2-ethylsulfonylphenyl)methyl]-5-(trifluoromethyl)benzamide (Compound D-18, 50.0 mg, 0.091 mmol) and DIPEA (47.0 μl, 0.272 mmol) in chloroform (1 ml), and the mixture was then stirred at room temperature for 16 hours.